Endocrine Abstracts

Aim: To identify the causes and predictors of mortality in acromegaly patients diagnosed, treated, and followed in the Pituitary Center of Istanbul University-Cerrahpasa over the last three decades using machine learning (ML) models.Methods: The study sample consisted of 607 consecutive patients diagnosed with acromegaly at Cerrahpasa Faculty of Medicine during the period 1990 – 2023. The main inclusion criteria were age > 18 years and a clear-c...

Objective: To determine the frequency of polycystic ovary syndrome (PCOS) in women with prediabetes compared to control women.Methods: Digital screening and tele-interviews remotely excluded 3218 out of 3465 consecutive women applied for routine check-up. In-person assessments were performed on 247 women, excluding 49. Final analyses included 198 premenopausal women without endocrine disorders (other than prediabetes and PCOS) or conditions affecting gon...

Objective: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is globally underdiagnosed and undertreated. This study aimed to search for the demographical characteristics, awareness and treatment adherence of underdiagnosed or undertreated FH patients from the records of the central biochemistry laboratory.Methods: Patient...

Aim: The association between thyroid autoimmunity and thyroid cancer has long been suggested, in addition whether and how the concurrent thyroid autoimmunity with Papillary Thyroid Carcinoma (PTC) affects clinicopathological features and prognosis is a matter of debate. In the present study, we aimed to evaluate the laboratory data, cancer characteristics and prognosis of PTC patients with and without thyroid autoimmunity.Materials and Methods: Data of 2...

Aims: Glycosylated hemoglobin (HbA1c) is a marker which demonstrates 3-month average level of blood glucose level. In individuals with high blood sugar level for a long time is associated with increased risk of cardiovascular disease (CVD). There is a need for simple and cost-effective markers to determine the risk of CVD in primary health care settings. In this study, we aimed to investigate the value of HbA1c for predicting cardiovascular risk in healthy non-diabetic individ...

Preoperative preparation of the hyperthyroid patient for thyroidectomy is imperative to avoid perioperative complications due to severe thyrotoxicosis. 24-years old woman was admitted at our clinic for uncontrolled Graves’ disease. In our case, agranulocytosis introduced by propylthiouracil. Therefore, surgery was the only chance of an effective therapy. In cases when the patient is unresponsive to medical therapy or when such therapy is contraindicated, therapeutic plasm...

Introduction: Association between ankle-brachial index (ABI) and coronary, cerebral, and peripheral vessels involvement has been shown in different studies. The normal range of ABI is between 0.9 and 1.4. Values below 0.9 show peripheral vessel disease. An ABI more than 1.4 is characteristic for vascular rigidity. We aimed to investigate the ABI value in our type 2 diabetic patients and association of ABI with glycemic control.Materials and methods: This...

Vitamin D has immunomodulatory features and its deficiency is associated with the development of autoimmune diseases. The relation between vitamin D deficiency and autoimmune thyroiditis has not been investigated much. In the present study, our aim was to study the relation between vitamin D therapy and autoimmune thyroiditis.Fifty-four patients having newly diagnosed Hashimoto thyroiditis (HT) and vitamin D deficiency but requiring no thyroid hormone re...

Introduction: Hypopituitarism is defined as either partial or complete deficiency of anterior or posterior pituitary hormone secretion or both. Hypopituitarism itself may increase the risk of thromboembolism/hypercoagulopathy, and underlying mechanisms of hemostatic dysfunctions in hypopituitarism are mostly unknown. Reduced enzymatic activity due to methylenetetrahydrofolate reductase (MTHFR) gene mutations are associated with hyperhomocysteinemia and have been linked to both...

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. Kickboxing is a novel cause of hypopituiatarism due to sports related traumatic brain injury (TBI) and isolated GHD is the most common problem (1).The present preliminary study was therefore designed to in...